Liquid Injection


Procaine penicillin G and Dihydrostreptomycin sulphate Injection(20:25)

Type:Liquid Injection
Release Date:2011/5/27 15:55:00


Each ml contains:

Procaine Benzylpenicillin (procaine penicillin).......................200 mg

Dihydrostreptomycin-Sulphate ................................................. 250 mg

The product also contains nipasept sodium as antimicrobial preservative and sodium formaldehyde sulphoxylate dihydrate as antioxidant.


A sterile white aqueous suspension for injection.


It is indicated for use in cattle, horses, sheep and pigs for the treatment of systemic infections caused by, or associated with, organisms sensitive to penicillin and/or streptomycin including:

Corynebacterium pyogenes, Erysipelothrix rhusiopathiae, Klebsiella pneumoniae, Listeria spp, Mannheimia haemolytica, Pasteurella multocida, Staphylococcus spp (non penicillinase producing), Streptococcus spp, and Salmonella spp.

It will therefore be effective in the treatment of infections caused by susceptible organisms including: Erysipelas, navel/joint-ill, respiratory tract infections, including pneumonia and atrophic rhinitis, listeriosis, meningitis, septicaemia, toxaemia associated with mastitis, urogenital tract infections, enteritis associated with Salmonella spp, salmonellosis and the control of secondary bacterial invaders in diseases of primary viral origin.

The combination of penicillin and dihydrostreptomycin is especially useful in the treatment of mixed infections involving both Gram-positive and Gram-negative organisms.


Shake the vial before use.

Administered by deep intramuscular injection.

Normal aseptic precautions should be observed.

Recommended dosage rate is 8mg/kg bodyweight procaine penicillin with 10mg/kg bodyweight dihydrostreptomycin sulphate equivalent to 1ml per 25kg bodyweight. Treatment should be given once daily for up to three consecutive days. The maximum dose volume administered at one site should not exceed 15 ml for horses, 6ml for cattle, 3ml for sheep and 1.5ml for pigs.



Contra-indicated in known cases of hypersensitivity to penicillin.

Not for intravenous or intrathecal administration.

Do not administer with other antibiotics such as tetracyclines or with other aminoglycosides.

Use with care in animals known to have kidney disease or defective renal function.

Do not exceed the recommended dosage or duration of treatment.

Animals must not be slaughtered for human consumption during treatment.


Cows: Milk: 60 hours.

Milk must not be taken during treatment.

Meat: 23 days.

Sheep: Not to be used in sheep producing milk for human consumption.

Meat: 31 days.

Pigs: Meat: 18 days.

Horses: Not to be used in horses intended for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation.

Aminoglycosides have a narrower margin of safety than beta-lactam antibiotics.

Pharmaceutical precautions

Do not store above 25°C.

Protect from light.

Keep out of the reach of children.

Following withdrawal of the first dose, use the product within 28 days.


Keep out of reach of children.